In Raina Telgemeier's Sisters, Raina and her little sister's relationship is under the microscope. Despite having always prayed for a little sister, Raina realizes as soon as her sister comes home with her parents that things may not exactly have worked out as she planned. Her sister is a fussy baby and often moody toddler who likes to play by herself. Plus, Raina herself has to learn to share space and time -- and of course, she struggles in the beginning. The sisters squabble over the years until a three-week family road trip from California to Colorado changes everything.
Guts is based on Telegmeier's experience with anxiety as a tween. After a case of the stomach flu in their family, Raina becomes terrified of vomit and vomiting. Her anxiety manifests physically as a stomachache which further exacerbates her fear of vomiting and intensifies her anxiety. Her parents take her to see a doctor who after multiple tests assures them that Raina is "healthy as a horse." Unsure what to do next, they take her to see a therapist.